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Abstract It has been known for many years that corticosteroid adtninstrations result in the destruction àf lymphoid tissue in certain animal species with subsequent shrinkage of spleen and lymph nodes and reduction in thymic weight and circulating lymphocytopenia C Bellaxiti, 1985). On the other hand. man as well as monkey and. guineaping is corticosteroid resistant, pharmacologic concentrations of corticosteroid in vivo and even suprapharmacolagic concentration in vitro do not result in lysis of normal lymphocyte in man. practically every functional capability of leucocytes can be suppressed if a high enough concentrations of corti— costeroid is added to cultring. Perhaps the major mechanism where by corticosteroid exert their anti—inflammatory effect in man is simply by preventing the accumulat of neutrophil at inflarnmat@ry site. However i1 appeo.r that the mJor neu.tropliil related effect of corticonteroith at Pharmacologic concentration in vio is to bipek cells from eaching the infls.nunatory site, witIi Relative sparing of actual functional apabilities ‘(BellantI, 1985) Aim of Work To study the effect of doxametjjaoonp oidjij phosphate on the phagocytic power of fleutrdphii. |