الفهرس 
CHAPTER IOnly 14 pages are availabe for public view
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Abstract
The thesis deals with the analysis of some selected drugs used in the treatment and management of gastrointestinal tract disorders. The selected drugs belong to several pharmacological groups such as antiemetics, antispasmodics, proton pump inhibitors, non steroidal anti-inflammatory drugs and muscle relaxants.
Chapter I This chapter includes a general introduction regarding chemical structures, molecular weights, physical properties, pharmacological actions and uses of the 9 investigated drugs and their analyzed products
ChapterII This chapter includes a literature review of the reported analytical methods for alverine citrate and chlordiazepoxide assay.
It describes a simple, rapid, and selective RP-HPLC method with UV detection for the simultaneous determination of alverine citrate and chlordiazepoxide hydrochloride. The chromatographic separation was achieved by using a RP- C8 analytical column. A mobile phase composed of acetonitrile - 0.05 M dibasic sodium phosphate - triethylamine (50 + 50 + 0.2, v/v/v), pH 2.5, was used; the detector wavelength was set at 210 and 246 nm for alverine and chlordiazepoxide, respectively. Quantification of the analytes was based on measuring their peak areas. The reliability and analytical performance of the proposed HPLC procedure was statistically validated with respect to linearity, range, precision, accuracy, selectivity, robustness, LOD, and LOQ. The linear dynamic ranges were 0.06 - 7.2 and 0.005 - 0.6 μg/mL for alverine and chlordiazepoxide HCl, respectively. The validated HPLC method was successfully applied to the analysis of the drugs combination in laboratory-prepared tablets and in plasma, for which no interfering peaks were encountered from common pharmaceutical adjuvants or endogenous plasma components. In order to assess the stability-indicating power of the assay procedure, the drugs were subjected to forced degradation under stress conditions of hydrolysis (acidic, basic and neutral), oxidation and photolysis. The photo diode array detector was used as a tool for peak identification and purity confirmation. The method was found to distinctly separate the peaks of the parent drugs from their degradation products .