الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Pyridazine derivatives have recently received much attention from their reactions, and also, since many pyridazine derivatives were found to possess potential therapeutic effects, one can expect that replacement of a heterocyclic aromatic moiety by the pyridazine nucleus in a bioactive molecule would alter the physiochemical characteristics of the latter significantly and hence also, its pharmacodynamics as well as pharmacokinetic qualities. Recently, triazole, thiazole and thiophene derivatives, which are both commercially available drugs and agents under clinical investigations, were the subject of a comprehensive review (Katritzky et al., 1996). Sulfonamides and sulfonylureas groups form the bioactive moiety of many compounds with therapeutically interest such as antibacterials, diuretics, antidiabetics and antibiotics (Lednicer et al., 1984). Also, mesoionic compounds have received much attention and have been extensively studied for their unique structures, reaction behavior and pharmaceutical activities (Newton et al., 1982).
All these properties aroused my interest in synthesizing new heterocyclic compounds including the triazolo, thiazolo and thieno pyridazine moieties and studying their biological activities as antibacterial and antidiabetic agents