الفهرس 
INTRUDUCTION AND AIM OF WORKOnly 14 pages are availabe for public view
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Abstract
hronic hemolytic anemia (CHA) is a common problem in pediatric
practice. It is caused by premature destruction of red blood
cells(RBCs), exceeding the capacity of bone marrow to produce
RBCs. Among the most common cause of CHA are thalassemias,
sickle cell disease, pyurvate kinase deficiency, hereditary spherocytosis .
Individuals with Chronic hemolytic anemia especially β-thalassemia
major suffer from severe anemia and hepatosplenomegaly; they usually
come to medical attention within the first two years of life. Without
treatment, affected children have severe failure to thrive and shortened
life expectancy. Treatment with a regular transfusion program and
chelation therapy, aimed at reducing transfusion iron overload, allows for
normal growth and development and extends life expectancy into the
third to fifth decade.
Accordingly, lifelong care is required, and financial expenditures
for proper treatment are substantial.
Chronic hemolytic anemia as a chronic disease is associated with
potentially compromised health-related quality of life for children and
their families .
Children with chronic hemolytic anemia have good survival but
little is known about their quality of life .
C
The aim of the study is to assess the clinical characteristics as well
as frequency of complications and assess quality of life. The response to
different therapeutic modalities .
Our study was retrospective demographic analysis of chronic hemolytic
anemia patients attending to outpatient clinic of hematology unit of Beni
–Suef university hospital.
In our study 150 patients were enrolled in this study .They were
diagnosed as chronic hemolytic anemia by clinical examination and
hemoglobin electrophoresis ;108 patients were diagnosed as Bthalassemia,
19 patients were diagnosed as sickle cell anemia ,19 patients
were diagnosed as G6PDD, While 4 patients were diagnosed as
hereditary spherocytosis.
All patients were subjected to detailed history taking, full clinical
examination, laboratory investigation (CBC, Hb level pre and post
transfusion, Serum ferritin level ,Kidney functions , abdominal US and
Hb electropharesis ) .
.Among our patients 65males and 85females ,61%had positive
family history and 65% had positive consanguinity.
According to Egyptian growth curves for height and weight
percentile respectively growth failure is detected .
Patients can be classified as:
Below 3rd percentile:51.9% of all population study.
from 3rd to 25th percentile :18.5%
>25 th percentile :34%
>75th percentile :12%
The study demonstrated the major complications affecting
chronic hemolytic anemia patients as hepatitis ,the study
demonstrated 16% of patients affected by HCV by PCR and
other hematological values.
The study demonstrated that hydroxyurea is the main stay of
treatment of β- thalassemia and sickle cell anemia provided that
monitoring of its side effects and revealed normal serum
creatinine level, normal serum Na and K and significantly
elevated BUN in thalassemic patients.