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Abstract Poultry, particularly chicken, is considered as an important source of animal-derived protein. The increasing competition in meat markets gives rise to the necessity of more and more efficient and competitive production. In this regard, production rates are fundamentally controlled by the sanitary aspects of the breeding stock The association of Escherichia coli strains with disease conditions in avian species was recognized over a century ago, but these strains were never accorded a special status. Escherichia coli, which is part of the normal microbiota of birds in intestinal and respiratory tracts, was considered as a potential pathogen. Lesions in which E. coli is the primary and often the secondary agent cause economic damage due to lower corporal development, insufficient feed conversion, increasing mortality, higher cost with medicine, and condemnation of carcasses. Today, E. coli strains causing systemic disease in poultry (avian colibacillosis) is termed avian pathogenic E. coli (APEC). Colibacillosis is a disease of economic significance to all poultry producers and is characterized by a diverse array of lesions. APEC strains fall under the category of extraintestinal pathogenic E. coli, which are characterized by the possession of virulence factors that enable them to live extraintestinallife. The aim of this study was to screen the epidemiological surveillance of APEC from various avian species distributed in Sharkia govemorate, Egypt including chicken, duck, turkey, pigeon, quail and ibis using the traditional diagnostic tools including bacteriological, biochemical and serological examinations. |