الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis including preparation and characterization of cellulose_based hydrogels, blends and hybrids for medical applications and was divided into three main parts. In the first part carboxymethyl cellulose was used to prepare pH sensitive hydrogels. Carboxy methylcellulose was modified by graft copolymerization of acrylic acid sodium salt. The obtained graft copolymers were then used in combination with sodium alginate to develop a new series of pH-sensitive interpenetrating network hydrogels through ionotropic gelation with Ca2+ ions. The release profiles of bovine serum albumin, were studied in different pHs. The data proved that, IPN hydrogels developed in this study can be tailored to act as potential carriers for oral delivery of protein drugs. In the second part , Polymer blends from chitosan/cellulose derivatives were prepared and characterized by FTIR, TGA, DSC and their antibacterial activity was also evaluated. Chitosan/cellulose ether blends exhibited good antibacterial activity. Films from chitosan and cellulose triacetatate were investigated and evaluated for use as Cu (II) adsorbents. The morphology and tensile strength of the previous blend films were also examined. In the third part, the ionic liquid 1-butyl-3-methylimidazolium chloride was used to grow cellulose/calcium phosphate hybrid materials. Preliminary studies with MC3T3-E1 pre-osteoblasts showed that the cells proliferate on the hybrid materials suggesting that the ionic liquid-based process yielded materials that were potentially useful as implantable scaffolds for regenerative therapies. Biocompatible mesoporous cellulose/silica hybrids were also prepared by an ionic liquid (IL)-assisted synthesis sol-gel route. All samples were mesoporous organic inorganic hybrid materials with surface areas between 70 and 120 m2/g and a uniform micro and macroscopic structure. |