الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
CCR1 and CCR5, Chemokine receptors, have been implicated in hepatic
inflammation and hepatocellular carcinoma (HCC). The rationale of the
present study was to investigate the expressions of CCR1, CCR5 on
peripheral blood mononuclear cells (PBMCs) of Egyptian patients with liver
cirrhosis and HCC and their correlation to the severity of liver disease and
the clinical features of HCC.
Isolated PBMC from the blood of 25 patients with HCC, 10 cirrhotic
liver patients and 9 adult healthy controls were stained with monoclonal
antibodies against CD4, CD8, CCR1 and CCR5, then detected by using a
flow cytometry technique. Patients were diagnosed by abdominal ultrasound
(US) and computed tomography (CT) scan findings, biochemical liver
function tests, serum alpha-fetoprotein (AFP). The severity of liver disease
was assessed by Child–Pugh score. Tumor characteristics were detected by
US and CT scan. These characteristics included tumor size, number and site.
Our data revealed that CCR1 and CCR5 expressions in liver cirrhosis
patients were significantly higher than healthy controls (P=0.008 and 0.053
respectively), as well as in HCC patients but the increment were not
significant (P= 0.120 and 0.216 respectively).
The expressions of CCR1 and CCR5 were increased in liver cirrhosis
than in HCC patients, but the increment were not significant (P=0.120 and
0.216 respectively). However, both CCR1 and CCR5 were decreased with
increasing number of liver tumor in a negative linear regression correlation
(P=0.607 and 0.941 respectively).