الفهرس 
Coronary Artery DiseaseOnly 14 pages are availabe for public view
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Abstract
Coronary Artery Disease (CAD) is the most common type of heart
disease. It is the leading cause of death in the world in both men and
women.
Coronary artery disease happens when the arteries that supply blood
to heart muscle become hardened and narrowed. This is due to the buildup
of cholesterol and other material, called plaque, on their inner walls. This
buildup is called atherosclerosis. As it grows, less blood can flow through
the arteries. As a result, the heart muscle can’t get the blood or oxygen it
needs. This can lead to chest pain (angina) or a heart attack. Most heart
attacks happen when a blood clot suddenly cuts off the hearts’ blood
supply, causing permanent heart damage.
Over time, CAD can also weaken the heart muscle and contribute to
heart failure and arrhythmias. Heart failure means the heart can’t pump
blood well to the rest of the body. Arrhythmias are changes in the normal
beating rhythm of the heart.
Endothelial Nitric Oxide Synthase (eNOS) plays an important role in
regulation of endothelial function and in the control of blood pressure.
The eNOS protein synthesizes nitric oxide constitutively via a
reaction including the conversion of L- arginine to L- citrulline.
A point mutation of guanine to thymine at nucleotide position
G894T in the endothelial nitric oxide synthase (eNOS) gene within exon 7,
resulting in a replacement of glutamic acid by aspartic acid at codon 298
(Glu298Asp), has been reported to be associated with Coronary artery
disease.