الفهرس 
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Abstract
Ofloxacin-loaded Gelrite in situ gel could be prepared using simple methodology. from the collected results, it can be concluded that:
1- The drug content, clarity and pH of the formulations were satisfactory.
2- The formulations exhibited pseudoplastic rheology, as evidenced by shear thinning. The viscosity was directly dependent on the polymeric content of the formulations.
3- Release studies conducted, using tear fluid, revealed a remarkable difference between the release profiles of the formed gel and the commercial drug eye drops.
4- The drug release rate was decreased when microspheres were incorporated into in situ gelling Gelrite.
5- Drug-polymer interactions was either absent or could not detected.