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Abstract Rift Valley Fever (RVF) is an infectious disease. The mean to control the disease was vaccination and eradication of vector. Many vaccines were used for this purpose, among them were locally prepared attenuated RVF vaccine and imported attenuated RVF vaccine. In this study, trials were conducted to compare between them Firstly, titration of original RVF virus vaccines on BHK cell line, the titer was 10’ TCI%0 / ml, 10’ TCIDeo / ml in locally and imported attenuated RVF vaccines respectively. Safety test was conducted by inoculating in hamster 0.5 ml I/P for both vaccines and both vaccines were safe. Physical examination of vaccinated animals showed slight elevation of body temperature post vaccination with either local or imported RVF vaccine. The virus was reisolated from serum samples containing from sheep and calves. Ocular, nasal and rectal swabs were obtained from vaccinated animals were free from the virus. One pregnant ewe vaccinated with locally prepared RVF vaccine (1 ml S/C) was aborted 10 th day after vaccination. Seroconversion studies using SNT, AGPT and ELISA revealed that the protective level was achieved in the first week post vaccination. Also, these studies recommended the use of local vaccine to control RVF disease. |