الفهرس 
Coronary Heart DiseaseOnly 14 pages are availabe for public view
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Abstract
Platelets play a dominant pathogenic role in the development and outcome of acute coronary syndrome. Platelet adhesion to the damaged vessel wall is the first step in development of thrombosis. Younger platelets are recently formed platelets called reticulated platelets which have large platelet volume & are believed to be more reactive hemostatically & express more P-selectin & glycoprotein IIb\IIIa.
The aim of this study is to evaluate the relationship between RPs, platelets size and platelets activity in patients with stable coronary artery disease (CAD) taking aspirin and clopidogrel.
This study was conducted on 60 patients with known stable coronary artery disease admitted to NHI for PCI; they were taking aspirin & clopidogrel, & 20 healthy individuals as a control group.
The comparison between patient & control groups revealed a statistically significant higher level of LDL in patient group, however no statically significant difference was detected regarding other risk factors as hypercholesterolemia, hypertriglyceridemia, hypertension & diabetes.
Our study demonstrated increase RP% & MPV in patients with stable CAD compared with control group also a significant difference was detected as regards percent & MFI of CD62 in patients compared to control group which means increase platelet reactivity.
In our study when we stratified patients into tertiles based on % RP, we found that MPV was significantly higher in the upper two tertiles reflecting the increase size of reticulated platelets. Moreover, patients in upper tertiles that express higher percentage of reticulated platelets showed significant increase in the percentage & MFI of CD62. No significant difference was detected among patient subgroups as regards risk factors and other hematological parameters.
A Significant correlation between MFI of CD62 and % RP was observed in our work means that RP are active platelets that have high level of procogulant surface like P-selectin and GP IIb/IIIa. No significant association was found between %RP and studied risk factors as hypertension, diabetes, smoking, dyslipidemia and family history