الفهرس 
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Abstract
This thesis includes three chapters; the first of which deals
with the synthesis of polyaza condensed heterocycles containing
1,2,4-triazino[5,6-b]indole ring as well as the methods of annelation
ofthe1,2,4-triazole ring from a-hydrazino heterocycles.
Chapter II is a discussion of the work carried out by the
Candidate.It deals with the versatility of the annelation of a triazole
ringto 5- and 8-substituted-I,2,4-triazino[5,6-b]indoles as well as the
synthesisof their seco- and diseeo C-nucleoside analogues. Thus, 3-
hydrazino-8-substituted-5H-I ,2, 4-triazino[ 5,6-b ]indole and 3-hydrazino-
5-substituted-l,2,4-triazino[5,6-b ]indole I were prepared and
their condensation with various aldehydes were carried out, whereby
the hydrazones II were formed. The dehydrogenative cyclization of
the prepared hydrazones with iron(III) chloride has been carried out,
and a model study was done on the acetaldehyde hydrazones,
wherebythe hydrazone II (Rl=H, R2=Me) gave 1,7-dimethyl-lOH-
1,2,4-triazolo[3’,4’:3,4][1,2,4]triazino[5,6-b ]indole IV (R2=Me),
while11(Ri=CHrCH=CH2, R2=H) afforded 1O-allyl-3-methyl-1 ,2,4-
triazolo[4’,3’:2,3][1,2,4]triazino[5,6-b ]indole ID (R 1=CH2-CH=CH2,
R2=H). In case of Il (Rl=H, R2=Br), 7-bromo-3-methyl-lOH-I,2,4-
triazolo[4’,3’:2,3][1,2,4]triazino[5,6-b ]indole ill (R l=H, R2=Br) was
obtained.
The selection of structure ID or IV for the products from the
oxidativecyc1ization of the hydrazones has been established.