الفهرس 
Systemic Lupus Erythematous and RANKLOnly 14 pages are availabe for public view
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Abstract
Systemic lupus erythematous is a multisystem, pleomorphic
disease in which inflammation, antibody production and complementfixing
immune complex deposition result in tissue damage. Although the
definite etiopathogenesis of SLE remains unclear, many different
mechanisms may contribute to the pathogenesis of SLE. Factors such as
sunlight and drugs could trigger the disorder, but no single cause has been
identified and SLE has a complex genetic basis.
RANKL is a tumour necrosis factor (TNF)-related cytokine
expressed by various bone cells including osteoblasts and their immature
precursors, T lymphocytes, B lymphocytes and megakaryocytes.
RANKL is a type II homotrimeric transmembrane protein that is
expressed as a membrane-bound and a secreted protein, which is derived
from the membrane form as a result of either proteolytic cleavage or
alternative splicing.