الفهرس 
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Abstract
This thesis includes three chapters; the first of which is a review of
themethodsutilized for the synthesis of the various types of tetraseconucleosideass
well as their biological activities.
The second chapter contains two parts deal with the synthesis of
dillereo; acyclic nucleosides mainly of the diseco- and tetraseconucleosidesr,
espectively. Thus, reaction of the 2(1H)-quinoxalinone with
5-chloro-3-oxapentylacetate afforded 1-(5-acetoxy-3-oxapentyl)- 2( 1/1)-
quinoxalinone(I) and 2-(5-acetoxy-3-oxapentyloxy)quinoxaline (ll),
whose deprotection of the hydroxyl group gave 1-(5-hydroxy-3-
oxapentyl)-2(1H)-quinoxalinone(llI) and 2-(5-hydroxy-3-oxapentyloxy)-
quinoxalin(IeV), respectively.
QN N V”o”””v ’>r--1
o
QN N
RO/”’-..../O~ o~
I R=Ac II R = Ac
llR=H IV R=H