الفهرس 
EPILEPSY
Pentylentetrazole (Metrazol,Sigma Aldrich Chemicals, USAOnly 14 pages are availabe for public view
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Abstract
Background &Aim: Enzyme -inducing antiepileptic drugs (AED) and epilepsy itself might be associated with increased vascular risk over time. We sought to determine whether a non-enzyme-inducing AED lamotrigine (LTG) has different effects on vascular risk markers in a rat model of kindling seizures induced by pentylepentetrazol (PTZ).
Methods: Four groups of male Wister rats were used. Vehicle control group, PTZ group (alternate day PTZ, 30mg/kg, i.p), LTG/PTZ group, (LTG 20 mg/kg/day p.o and alternate day PTZ) and LTG alone group. The study period was 5 weeks.
Results: Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), homocysteine (Hcy) and both serum and aortic malondialdehyde (MDA) levels were significantly higher in kindled rats compared to normal controls rats. Associated with a significant decrease in both serum, aortic glutathione (GH) and serum high density lipoprotein (HDL), with high atherosclerotic index. LTG/PTZ rats exhibited significant decrease the PTZ-kindled seizures, TC, TG, LDL, both serum and aortic MDA. Along with significant increase in HDL, no beneficial effect on the increased Hcy level and improvement of both vascular reactivity of the isolated aortic rings preparations in comparison to epileptic rats. LTG alone decreased all serum lipids, aortic GSH but increased Hcy and aortic MDA levels. Histopathological examination revealed that LTG has a neuro and cardiovascular protective effects as indicated by decreased neurodegeneration and atherosclerosis of aortas and coronaries.
Conclusion: LTG produced a significant improvement in vascular risk markers and seizures control in this rat model of kindling seizures.
Key words: Antiepileptic drugs; lamotrigine; epilepsy; vascular risk; Pentylentetrazole; homocysteine.