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العنوان
Relation between Fibrinolytic Activity and Synthetic Function in Patients with Liver Cirrhosis /
المؤلف
Mohamed, Shereen Mostafa.
هيئة الاعداد
باحث / Shereen Mostafa Mohamed
مشرف / Ayman Gamel Ghobrial
مشرف / Lamia Hamdy Ali Abd EL Hak
مشرف / Manal Mohamed Saber
الموضوع
Liver - Diseases - Etiology. Hepatitis - Etiology. Liver Diseases - Etiology.
تاريخ النشر
2012.
عدد الصفحات
127 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
تاريخ الإجازة
1/1/2012
مكان الإجازة
جامعة المنيا - كلية الطب - Clinical Pathology Dep.
الفهرس
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Abstract

The present study included fifty five subjects, forty patients with liver cirrhosis and fifteen apparently healthy subjects. Cirrhotic patients are divided into 2 groups, group I ( decompansated liver cirrhosis group), group II (compansated liver cirrhosis group ).
All patients and control were subjected to: Random blood glucose ,Kidney function tests, Liver function tests,Complete blood count,Prothrombin time ,Activated partial thromboplastin time ,Special investigations including Factor VIl, Fibrinogen, D-dimer.
The results of this study were summarized as follows:
Prothrombin conc was significantly decreased in group І when compared with group П and group III.Fibrinogen , FVII were significantly decreased in group I when compared with group II and group III. D-dimer was significantly increased in group І when compared with group П and group III . This study revealed :-There is a state of hyperfibrinolysis in decompansated cirrhosis , either primary or secondary to a low grade DIC or a hypercoagulable state.-There is strong relationship between hyperfibrinolysis and indices of liver synthetic function either routine tests ( PT, APTT) or F VII and fibrinogen. This may be due to consumption of factors or the anticoagulant effect of FDPs (as regards PT and APTT).