الفهرس 
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Abstract
The wide distribution of thrombotic disorders necessitates the introduction
of a wider range of thrombolytic agents. At present the search for effective
proteinases is of great significance for their production since plasmin, most widely
used for thrombolytic treatment, is not readily available and cannot completely
satisfythe demands of hospitals (Egorov, 1978; Andreenko, 1985).
Plasminogen (or profibrinolysin) is the precursor of the enzyme plasmin (or
fibrinolysin) which is present in blood serum and is capable of hydrolysing fibrin
(Sherry et al., 1959).
Fibrinolytic enzymes have a great significance in thrombosis therapy in
man. Great attention has therefore been directed toward the search for new
thrombolytic agents of various origins especially from microorganisms. Tillet and
Garner (1933) discovered a bacterial enzyme capable of thrombus dissolution.
Streptokinase is one of the major blood-clot-dissolving agents used in many
medical treatments, it is a group of extracellular proteins produced by a variety
of beta-hemolytic Streptococci (Martin, 1982).
Productionof fibrinolytic enzyme from different microbial sources
a- Production from fungi
Many authors reported on the production and isolation of enzymes with
fibrinolyticactivity from fungi, especially from Aspergillus oryzae (Aspergillin 0).
This preparation was purified to yield a highly active enzyme (Stephanini et ai,
1959; Bergkvist, 1963a,b,c & d; Berkvist and Svard, 1964; Ives and Tosoni, 1967).