الفهرس 
ObesityOnly 14 pages are availabe for public view
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Abstract
The total amount of an adipokine secreted from white adipose tissue may affect whole-body homeostasis. The dysregulated secretion of adipokine not only from adipocytes, but also from macrophages in white adipose tissue can contribute to pathogenesis of obesity-related health problems. It has been suggested that weight loss affects the immune system by reducing the number of mononuclear cells in peripheral blood and endothelial cells and macrophages that reside in adipose tissue which are all sources of proinflammatory cytokines such as TNF-a and CRP.
The present work was undertaken aiming to evaluate the effect of obesity on serum concentrations of TNF-a and hs-CRP, and to determine the effect of weight loss after gastric bypass on the low grade inflammatory state associated with obesity through measuring the levels of the above parameters.
Three groups of individuals were included in the study; group I, including 20 morbidly obese individuals with mean (BMI) 61±15.83 kg/m2, group II, including 20 morbidly obese individuals after significant weight loss induced by gastric bypass with mean BMI 51.4±6.01 kg/m2, and group III which included 15 age and sex matched normal weight controls with mean BMI 21.03±2.45 kg/m2. Quantitative assays of serum TNF-a and (hs-CRP), using commercially supplied ELISA were performed for all individuals. In addition to the assessment of serum cholesterol, SGPT and fasting blood sugar.
Statistically high significant differences as regards serum levels of TNF-a and hs-CRP were found between the 3 studied groups with group I having the highest levels. Furthermore, serum cholesterol and SGPT showed statistically significant higher levels in group I when compared to group II. Additionally, correlation studies have revealed significant positive correlations between TNF-a and each of hs-CRP, BMI, serum cholesterol and SGPT among obese individuals.
According to the results of the present study; it was concluded that high serum levels of TNF-a and hs-CRP are associated with obesity and that lowering body weight might induced fall of those proinflammatory mediators. Additionally, the correlation between serum TNF-a and serum SGPT and total cholesterol suggests that the dysregulated adipokine secretion might contribute to obesity-related health problems. Therefore, beside trials to achieve sustainable weight loss, drugs that act to normalize adipocyte functions might be useful.