الفهرس 
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Abstract
epatocellular carcinoma (HCC) is the fifth most
common cancer worldwide and the third leading
cause of cancer-related mortality after lung and stomach cancers (Al Knawy et al., 2009). In Egypt, the annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (El-Zayadi et al., 2005).
The aim of this study was to evaluate the diagnostic value of Glypican 3 as a tumor marker of HCC.
This study was conducted on 90 persons who were
divided into three groups:
Group I (HCC group); included 30 patients with HCC on the background of liver cirrhosis. Thire ages ranged between 47-65year (median=54.00).
Group II (chronic liver disease group); included 30 patients with chronic liver disease without any evidence of hepatic focal lesions as excluded by ultrasonography and AFP estimation. Diagnosis of chronic liver disease was based on standard clinical, biochemical, ultrasonographic criteria and pathological data whenever feasible. Thire ages ranged between 45-61 years (median=51.50).
Group III included 30 normal subjects who served as the control group.
The Study determined the level of GPC-3 in all cases of Groups together with full history, clinical assessment, liver biochemical profile, viral markers, conventional US and triphasic abdominal CT scan.
As regards the past history and etiological factors of HCC;parenteral therapy for schistosomiasis was recoded in 66.7%,and smoking was recorded higher 53.3% in HCC group.
Serum AFP was significantly elevated in HCC group (Median = 46.8 ng/ml) when compared with chronic liver disease (6.7 ng/ml) group.
GPC-3 level was also significantly elevated in the HCC group (Median = 13.6%) when compared with both the control (0.49 %) and chronic liver disease (1.9 %) groups, so this statistical significant difference implies the diagnostic role of
GPC 3 in detection of HCC in cirrhotic patients.
A non-significant differences were found on comparing HCC Child A ,HCC Child B and HCC Child C and serum level of GPC 3.
It was also found that when using a cut off level of GPC- 3 at 2.6 % (best cut off level for the study) it had a sensitivity of 100 % and a specificity of 93.3 %.