الفهرس 
PART IOnly 14 pages are availabe for public view
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Abstract
The thesis comprises four parts:
Part I
This part contains a short account about inflammation. The pharmacological action of nonsteroidal anti-inflammatory drugs (NSAIDs) is also discussed. This part mainly contains a general introduction about the chemical names, structures, physical properties, pharmacological actions and uses of the investigated drugs. Detailed literature reviews are presented showing the reported methods for analysis of the selected drugs in pharmaceutical preparations as well as in biological fluids.
Part II
This part deals with the development and validation of several spectrophotometric methods for the determination of nabumetone (NAB) in pure form and in its tablets dosage form. The methods are based on the reaction of nabumetone with several dinitrobenzene reagents, namely, m-dinitrobenzene (DNB), 1-chloro-2,4-dinitrobenzene (CDNB) and 1-fluoro-2,4-dinitrobenzene (FDNB) in alkaline medium (alcoholic potassium hydroxide solution). The studied reactions depend on the tendency of these dinitrobenzene reagents to react with the active methylene adjacent to a carbonyl group. DNB reacts through the formation of meisenheimer sigma-complex while CDNB and FDNB introduce a chromophore group by nucleophilic substitution reaction. Spectrophotometric measurements were achieved by recording the absorbances at λmax 580, 573 and 574 nm for the reaction with DNB, CDNB and FDNB respectively. The different experimental parameters affecting the development and stability of the produced colors were carefully studied and optimized. The three methods were validated with respect to linearity, ranges, precision, accuracy and limits of detection and quantitation. Beer’s law was obeyed in the concentration ranges of 2-10, 40-240 and 10-50 µg/mL for DNB, CDNB and FDNB methods respectively with correlation coefficient values not less than 0.99945. In addition, detection limits of NAB were 0.27, 8.54 and 2.04 µg/mL for DNB, CDNB and FDNB methods, respectively. The proposed methods were successfully applied for the assay of the drug in its tablets dosage form. Recovery data obtained by the proposed methods were favorably compared with those obtained by a reported spectrophotometric method using the one-way analysis of variance test (single factor ANOVA). In addition, illustrative proposed reaction pathways showing the reaction of NAB with the three dinitrobenzene reagents were presented.