الفهرس | Only 14 pages are availabe for public view |
Abstract FMF is a potentially lethal disorder that adversely impacts the affected subjects: social. familial and work life despite that it is not recognized by the governmental health authorities as a ”national disease ”, FMF receives only a fraction of attention it deserves. It will be one of the most important medical concerns of the coming decades as the carriers of the disease asymptomatic and not known and married with carriers with affected siblings. The diagnosis based on a typical clinical picture of recurrent attacks of fever and pain affecting patients, and involving one or two of the following sites at a time: abdomen, chest, joints, muscles, and skin. In addition, an increase in acute phase reactants during the attacks, a positive history among siblings or in the extended family, and a good response to colchicine helped to establish the diagnosis. However, genetic diagnosis is essential to confirm the diagnosis .Moreover; genetic analysis may be very useful in preventing the occurrence of renal amyloidosis. |