الفهرس 
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Abstract
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable
disease state characterized by airflow limitation that is not fully reversible. The
airflow limitation is usually progressive and is associated with an abnormal
inflammatory response of the lungs to noxious particles or gases, primarily caused
by cigarette smoking. Although COPD affects the lungs, it also produces
significant systemic consequences.
Visfatin is a newly discovered adipocytokine which has a relationship with
COPD.
The aim of this work was to evaluate serum visfatin level in patients with COPD
and its correlation with other inflammatory markers as CRP.
This study included 55 subjects classified as:
Group I: It included 35 patients suffering from chronic obstructive pulmonary
disease, their ages ranged from (46-69) .They were selected from inpatients
departments of Shebeen El-Kom Chest Hospital.
Group II: It included 20 apparently healthy volunteers, gender and age matched
as a control group, their ages ranged from (46-67).
All subjects were submitted to full history taking , general clinical
examination, local examination of the chest, anthropometric measurements
(weight, height , body mass index and waist circumference ), routine investigations
as CBC, ESR, liver and kidney function tests , fasting blood sugar, measurement
of FEV1% , serum visfatin by ELISA and serum highly sensitive C-reactive
protein by ELISA.
Statistical comparison was done between patients and control groups.
The results of the current study showed: The studied groups were well
matched as regard age, gender.
* As regards the demographic criteria:
There was statistically significant difference between COPD and control
groups regarding the mean height and BMI (lower in COPD), while waist
circumference is higher in COPD. However, no significant statistical difference
detected between studied groups regarding weight.
*As regards the biochemical markers :
There was statistically significant difference between COPD and control
groups regarding serum creatinine and albumin (lower in COPD) while ESR is
higher in COPD. However, no significant statistical difference detected between
studied groups regarding urea, liver enzymes, bilirubin, glucose and WBCs count.
*As regards FEV1%:
There was statistically significant difference between COPD and control
groups regarding FEV1% (lower in COPD).
*As regards the visfatin level :
The mean visfatin levels were higher in COPD patients compared to controls.
*As regards correlation between visfatin level and other studied parameters :
There were significant positive correlation between visfatin and each of waist
circumference, ESR, CRP and smoking. There were significant negative
correlation between visfatin and each of FEV1%, albumin. There were no
significant statistical difference between visfatin and each of age, height, BMI,
weight, urea, creatinine, liver enzymes, bilirubin, glucose and WBCs.
In an attempt to investigate whether serum visfatin concentration can play
role in pathogenesis of COPD, this study found that the cutoff value for serum
visfatin 18.5 ng/ml that gives sensitivity of 86%, specificity of 100%, PPV 100%,
NPV 80% and accuracy 91% is used for differentiation between controls and
subjects with COPD.