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العنوان
Study of the Chemical Structure and Biological Effect of Some Metal Ions on the Efficiency of Therapeutic Materials /
المؤلف
Mohamed, Hammad Fetooh Abd-Elghafar.
هيئة الاعداد
باحث / حماد فتوح عبدالغفار محمد
مشرف / حماده محمد احمد كيله
مشرف / جهاد جنيدى محمد جنيدى
مشرف / محمد يسرى السيد ابراهيم
الموضوع
Therapeutics. Chemistry.
تاريخ النشر
2012.
عدد الصفحات
158 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Chemistry (miscellaneous)
تاريخ الإجازة
1/1/2012
مكان الإجازة
جامعة الزقازيق - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

Complexes of Mg(II), Ca(II), Ba(II) and Sr(II) with paracetamol drug were
synthesized and characterized by elemental analysis, conductivity, UV–Vis, IR, 1HNMR
spectroscopy and thermal analysis, as well as screened for antimicrobial activity.
The IR spectral data suggested that the ligand behaves as a neutral bidentate ligand
coordinated to the metal ions via the lone pair of electrons of nitrogen and carbonyl-O
atoms of the amide group. from the microanalytical data, the stoichiometry of the
complexes reacts with Mg(II), Ca(II), Ba(II) and Sr(II) by molar ratios (2:1)
(paracetamol: metal). The thermal behaviour (TG/DTG) of the complexes was studied
and kinetic parameters were determined by Horowitz–Metzger and Coats–Redfern
methods. The ligand and its metal complexes were screened for antibacterial activity
against and fungicidal activity.