الفهرس | Only 14 pages are availabe for public view |
Abstract Complexes of Mg(II), Ca(II), Ba(II) and Sr(II) with paracetamol drug were synthesized and characterized by elemental analysis, conductivity, UV–Vis, IR, 1HNMR spectroscopy and thermal analysis, as well as screened for antimicrobial activity. The IR spectral data suggested that the ligand behaves as a neutral bidentate ligand coordinated to the metal ions via the lone pair of electrons of nitrogen and carbonyl-O atoms of the amide group. from the microanalytical data, the stoichiometry of the complexes reacts with Mg(II), Ca(II), Ba(II) and Sr(II) by molar ratios (2:1) (paracetamol: metal). The thermal behaviour (TG/DTG) of the complexes was studied and kinetic parameters were determined by Horowitz–Metzger and Coats–Redfern methods. The ligand and its metal complexes were screened for antibacterial activity against and fungicidal activity. |