الفهرس 
COVEROnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
Coronary heart disease is a leading cause for and
mortality in many countries world-wide. Despite the search for novel risk factors, established ones still play a major role.
These are the dyslipidaemias, hypertension, cigarette smoking,diabetes, obesity and physical inactivity (Lee et al., 2001).
Haemostasis plays an important role in the development of cardiac complications (Lisowski et al., 2004).
Tissue factor, formerly known as thromboplastin (Steffel et al., 2006), is membrane-bound on monocytes (mTF) and free in plasma (fTF) (Vieira et al., 2007), it is not normally exposed
to circulating blood, but may be produced by endothelium and monocytes under pathological conditions (Siddiqui et al.,2002). Tissue factor is the main physiological initiator of blood
coagulation (Vieira et al., 2007). It binds and acts as an essential cofactor for active factor VII (FVIIa) (Soejima et al.,1999). It is also a signaling receptor. Blood borne tissue factor has an important procoagulant function in sepsis,
atherosclerosis, cancer and other functions beyond haemostasis such as immune functions and metastases (Price et al., 2004).
The active tissue factor present in the atherosclerotic vessel wall is proposed to be responsible for the major complications
of primary atherosclerosis, namely, acute thrombosis after plaque rupture (Crawley et al., 2000), where its contact with circulating blood after plaque rupture leads to activation of the
coagulation cascade (Maly et al., 2003). Therefore its high levels may be the mechanism of action responsible for the increased thrombotic complications associated with the presence of cardiovascular risk factors (Sambola et al., 2003).
The present study aimed to evaluate the role of tissue factor in peripheral blood in the pathogenesis of coronary heart diseases, as well as its relation to disease severity. The study
was carried out on 60 coronary heart disease patients (20 were AMI, 20 were unstable angina and 20 were stable angina).
Another 20 healthy individuals of matched age and sex were included as a control group. Plasma tissue factor showed values of 162.5 ± 50.98, 174.25 ± 63.08, 114.25 ± 37.53 and 74.25 ±
31.05 pg / ml. for myocardial infarction, unstable angina, stable angina and control groups; respectively.
On Comparing mean TF level in the patients group (150.33 ± 57.07) and the control group (74.25 ± 31.05) it revealed statistically highly significant elevation in patients group when compared to control group P<0.0001.Cases of
myocardial infarction and unstable angina groups showed statistically significant higher means when compared to stable angina group (P<0.0001). Although the TF level in group 2(unstable angina) was found to be slightly higher than in group1 (myocardial infarction), there was no statistical
significant difference between both of them (P=0.52), and collectively, a statistical significant difference between the three groups together was found (P=0.001).
Regarding the influence of TF on the severity of CHD (angiographicaly) although, in this study no significantdifference between mean TF levels among subjects with single,two and three vessels disease, gradual rise in the mean TF levels between the three groups was observed. In conclusion,our study demonstrated that the plasma level of TF is elevated in all types of coronary heart diseases than control group with
no significant difference in neither the studied cardiovascular risk factors neither the disease severity.
Conclusion
Our study demonstrated that the plasma level of TF is elevated in all types of coronary heart diseases than control group with no significant difference in neither the studied cardiovascular risk factors neither the disease severity.