الفهرس 
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Abstract
Acne vulgaris is one of the common dermatological disease frequently found in late childhood and adolescence . Sebaceous hyperplasia, follicular hyperkeratinization, and bacterial hypercolonization, as well as immune reactions and inflammations may lead to acne, which has a quite complex pathogenesis . Propionibacterium acnes produces follicular lipases, proteases, and hyaluronidases, several enzymes that may play an important role in the inflammatory process .
Besides, many researchers think that acne pathogenesis can not exactly be understood.
In acne, sebum produced by sebaceous glands, content changes and reactive oxygen species (ROS) may be released from the impacted damaged follicular walls; at the same time it is thought that this may be the reason for the progress of the inflammation in the pathogenesis of the disease . It is also known that some of the drugs used commonly in the treatment of acne function by decreasing ROS .
Oxidative stress is the shift in ratio between oxidants and antioxidants either due to excessive ROS generation and/or decrease in antioxidant defenses. An antioxidant is any substance that, when present at low concentrations compared with those of an oxidizable substrate significantly delays or prevents oxidation of that substrate. They are either preventive inhibitors (prevent the initiation of free radical attack) as catalase and superoxide dismutase (SOD) or chain breakers as vitamin and ascorbic acids. These chain breakers convert free radicals to stable products thus block free radical chain reactions.
Reactive oxygen species is a collective term including oxygen free radicals such as superoxide and hydrogen peroxide and some non radical derivatives which may yield free radicals in the presence of transitional metal ions .
Superoxide dismutase (SOD) are a class of closely related enzymes that catalyze the breakdown of the superoxide anion into oxygen and hydrogen peroxide. Malondialdehyde (MDA) is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism .
This controlled study was carried on thirty seven subjects (twenty seven patients with acne) and (ten apparently healthy persons as control group) they were 29 females and 8 males with age ranging from (13-25)years. The patients were attendants of out patients clinic of Dermatology Department, Menoufia University Hospital during the period from December 2011 to April 2012 . and none of them had any other coexistent disease. None of them had alcohol abuse problems and smoking. Prior to initiation of the study, each subject was informed about the aim of the study and signed an informed consent. all patients were subjected to full history taking(personal, present, past, family and menstrual history and marital state).
Detailed dermatological examination was performed to classify the acne severity, and to note the site of acne extension. The distribution of lesions in patients includes face and body (fore and/or back) covering.
Laboratory investigation were measured for both patients and controls including serum Malondialdehyde (MDA) and serum superoxide dismutase(SOD).