الفهرس 
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Abstract
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Human schistosomiasis is a Socio-economic and health problem in
Egypt and many other countries. Although much is known about
-schistosoma and its related diseases, the biochemical changes which lead
to cell apoptosis is not well investigated. Therefore, the casual relationship
between schistosomiasis and cancer is uncertain [1 ].However, bcl-2 is one
of the cellular proteins which regulate the occurrence of apoptosis [2 ]. bel-
2 is unique in that gene expression results in prolonged cell life-span by
preventing apoptosis [3 ]. Thus, it increases the risk of acquiring genetic
changes resulting in malignant transformation [4,5]. bcl-2 can cooperate
with viral or other cellular protooncogenes in the process of
tumorogenesis, both in vivo and in vitro [6 ] and its expression has been
reported in a variety of malignancies [7,8 ]. Also, NO was recognized as a
cytotoxin and released during several physiopathological events, including
immunnological reactions and inflammation [9]. Moreover, there are no
available studies which addressed the relationship between expression of
bc1-2 and NO that present when schistosomiasis -associated with hepatitis
’C’ virus (HCV).
Taken together, the present study is undertaken to investigate the
correlation between bcl-2 level in schistosomiasis-associated HCV and
schistosomiasis. Also, it involves the investigation of the possible
correlation between NO induction and bcl-2 level in these patients.
Therefore, it was recommended to use flowcytometer as a research tool.