الفهرس | Only 14 pages are availabe for public view |
Abstract Degradable polymeric biomaterials are preferred candidates for developing therapeutic devices. Biodegradation of polymeric biomaterials involves cleavage of hydrolytically or enzymatically sensitive bonds in the polymer leading to polymer erosion. Amino acids are among the simplest biomolecules that contain intramolecular hydrogen bonds and they serve as building blocks of more complex peptides and proteins. Polies (amino acids) are ubiquitous, naturally-occurring biodegradable polymers; however, their application as a biomaterial has been limited due to immunogenicity and poor mechanical performances. To overcome these limitations, attempts have been made to develop amino acids based synthetic polymers. Amino acid based synthetic polymers are also expected to show biocompatibility and biodegradability similar to those of polypeptides. Among the synthetic. |