الفهرس 
Anatomy of the LimbusOnly 14 pages are availabe for public view
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Abstract
Management Of Limbal Stem Cell
Deficiency
By:Noha Maher.
The limbal stem cells are responsible for corneal epithelial
renewal and regeneration, and function as a barrier, preventing
conjunctival epithelium from growing onto the cornea.
A damaged corneal surface will reduce visual acuity and can
ultimately lead to blindness. Following ocular surface injuries,
these cells are responsible for the replacement of the stratified
epithelium covering the cornea.
Diseases that destroy Limbal epithelial stem cells (LESC) or
their stromal micro-environment can lead to LSCD.LSCD is
characterized by progressive invasion of conjunctival epithelial
cells onto the cornea, superficial vascularisation, destruction of
the corneal basement membrane, and chronic inflammatory cell
infiltration.
Limbal stem cell deficiency (LSCD) may be primary or
secondary. Also can be classified as partial or total. LSCD is
manifested by decreased vision, redness, photophobia, Clinical
sings includes; opacification and vascularisation of the cornea.Currently, there is no drug therapy for limbal stem cell failure,
and the treatment is therefore mostly limited to surgical
intervention as the means of restoring the ocular surface in cases
with limbal stem cell deficiency.
Reestablishing the tear film and the ocular surface anatomy is
critical for maintenance of the micro environment essential for
limbal stem cell survival e.g. mucus membrane transplantation
and replacement therapy for dry eye. Maintenance of the micro
environment also includes management of the underlying
systemic disease and ocular adnexal pathology.