الفهرس | Only 14 pages are availabe for public view |
Abstract Acne vulgaris is a common almost physiologic skin condition that is likely to affect up to 80% of people between the age of 11 to 30 years. A significant proportion may eventually result in scarring that is usually related to the severity of preceding inflammation, stage and nature of treatment, nature of local manipulation, as well as individual predisposition to scarring. Several techniques have been suggested for the treatment of acne scars that vary in nature and reported efficacy according to the type and severity of the treated scar. These include surgical techniques e.g. dermabrasion, microdermabrasion, punch excision, punch grafting, punch elevation, and subcision, as well as non-surgical techniques e.g. radiofrequency fillers, peeling, laser (ablative or nonablative), plasma skin regeneration, and intense pulsed light.In this study we tried to asses to assess the use of whole plasma or the so called platelet-poor plasma as a natural filler in treatment of superficial atrophic distensible post acne scars In this study, 32 patients suffering from superficial distensible post acne scars of the face were divided into 4 groups (with 8 patients in each group): group AI: Patients were treated by injecting PPP only. group AII: Patients were treated by injecting PPP followed by Dermaheal HSR® (Lamelle research laboratories. Korea) group BI : Patients were treated by injecting PPP followed by oral intake of (KapronR) tablets. group BII: Patients were treated by injecting PPP followed by Dermaheal HSR® injection, followed by oral intake of (KapronR) tablets. In all groups, patients received 3 sessions with a 2 week-interval between sessions and follow up was done after 12 weeks. The study could show that all the four groups showed significant improvement but with some variation in the percentage of the improvement between the groups. After the follow up period, group BII showed the best results with an average improvement of 46% (± 0.170), this was followed by group AII with an average improvement of 40% (± 0.185) then group BI with an average improvement of 25% (± 0.258) and lastly group AI with an average improvement of 22% (± 0.194). It was also noticed that in all the 4 groups, the greatest degree of improvement was observed after the first session followed by less noticeable improvement after each session. After completing the sessions and during the follow up period, a certain degree of regression was noticed in all groups. So, in view of the present study, PPP injection seems promising as an easy and cheap technique to correct such filling defects as scars and wrinkles at least as an ancillary line of treatment. Nevertheless, many variables in the technique are yet to be standardized for optimum efficacy. To get better results, the technique may be supplemented by local injection of an appropriate fibroblast stimulating agent(s) +/- additional administration of an appropriate antifibrinolytic agent. Further evaluation and more prerequisites are needed before firm conclusions can be made about that technique. These include trial on a larger number of patients, long term follow up as well as histopathologic examination of the injected sites to document the histopathological changes that took place at the injected sites. |