الفهرس 
Virology & FibrogenesisOnly 14 pages are availabe for public view
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Abstract
Hepatitis B is a worldwide health care problem especially in the developing countries; & it is the 10th leading cause of death worldwide. The
consequent liver fibrosis also represents a major medical problem worldwide
that is associated with significant morbidity and mortality. Beyond being a
marker of injury, it appears to play a direct role in the pathogenesis of
hepatocellular dysfunction and portal hypertension. Thus assessing the
extent and progression of fibrosis is important for treatment decisions&
monitoring and prognosis of the cases.
Liver biopsy is still the gold standard for fibrosis staging, although it is
limited by its invasive nature, poor acceptance, availability, cost, intra- and
interobserver variability, and sampling errors.
Alternative tests for liver fibrosis evaluation have been developed. Among
them, direct & indirect serum markers and transient elastography (fibroscan)
are the two main techniques which have been compared against histology.
The aim of the study was to evaluate non invasive tools in assessment of
liver fibrosis in patients with chronic hepatitis B. we included the fibroscan,
APRI score, FIB4 score & Fibroαscore.
Our study is a cross sectional study, included 30 chronic HBV patients as
diagnosed by positive HBsAg (persistent for more than 6 months) & with
detectable serum quantitative HBV-DNA. Patients were referred from
Hepatology outpatient clinic, National Hepatology and Tropical Medicine
Research Institute (NHTMRI) and hepatology outpatient clinic at Ain
Shams University Hospital.