الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acute kidney injury is generally defined as ’an abrupt and sustained
decrease in kidney function’. Acute Dialysis Quality Initiative (ADQI)
formulated the Risk, Injury, and Failure, Loss, and End-stage Kidney
(RIFLE) defines three grades of increasing severity of acute kidney injury -
risk (class R), injury (class I) and failure (class F) - and two outcome
classes (loss and end-stage kidney disease). It depends on serum creatinine
and urine output as markers of renal function.
Depending on traditional markers for renal functions, namely blood
urea and serum creatinine, has lead to unacceptable delay in diagnosis and
in initiating treatment.
Our study aimed at depicting the role of KIM-1 as an early marker
for AKI.
The present study included 89 subjects that have been classified
into 3 groups:
Group 1: 44 critically-ill patients who developed AKI.
Group 2: 35 critically-ill patients who didn’t develop AKI
Group 3: 10 healthy subjects were taken as control.
Both patients & control groups in the study have been subjected to
thorough history taking, complete clinical examination, routine laboratory
investigations including full blood count, fasting blood sugar, liver profile,
ESR, arterial blood gases, electrolytes, pelvi-abdominal ultrasonography
and urinary KIM-1.
Summary
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Blood urea, serum creatinine and urinary KIM-1 were withdrawn
from all patients at admission, then at time of admission & 6 and 12 hours
intervals.
The results of this study may be summarized as follows:
• KIM-1 can detect acute kidney injury as early as 6 hours
from its occurrence and before elevation of the conventional
markers by 48 hours at least.
• KIM-1 is ( unlike the conventional markers ) not influenced
by age, sex and body mass index.
• KIM-1 is a reliable indicator of morbidity and mortality in
critically ill patients.
• KIM-1 after 6 hours has a sensitivity of 100% and a
specificity of 97.1%.
• KIM-1 after 12 hours has a sensitivity of 100% and a
specificity of 100%.