الفهرس 
ACKNOWLEDGMENTOnly 14 pages are availabe for public view
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Abstract
Perinatal HIE is associated with high neonatal mortality and severe long-term neurologic morbidity. Recently, six large trials have confirmed an association between 72 hours of therapeutic hypothermia in infants with neonatal encephalopathy and a significant reduction in death and disability at an 18-month of age. Yet, although the evidence from completed trials confirms that therapeutic hypothermia improves outcome, 40%-50% of infants treated with hypothermia still depart this life or experience significant neurologic disability. Therefore, there is a pressing necessity to refine current hypothermia treatment protocols and to develop additional treatment strategies.
This study was a pilot study in a double blinded randomized control manner that involved 30 fullterm newborns moderate and severe HIE. They were assigned to two different groups; each group includes 15 newborns. Patients in both groups were exposed to selective head cooling, which started within the first six hours after birth, for target rectal temperature between 33.5-34.5ºC.