الفهرس 
INTRODUCTION AND Aim Of The WorkOnly 14 pages are availabe for public view
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Abstract
The poultry industry in recent years has occupied a leading role among agricultural industries in many parts of the world. The potential for further growth is obvious in view in the value of eggs and poultry meat as basic protective foods in the human diets.
Cholesterol is not a life-threatening toxin, it has many benefits, but cholesterol can also create problems. Cholesterol in the bile can crystallize to form gall stones that may block the bile ducts. Cholesterol is also strongly implicated in the development of atherschelorosis: fatty deposits (plaques) that form on the inside of blood vessels and predispose to heart attacks. The major culprit seems to be levels of LDLs that are in excess of the body’s needs.
Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, have revolutionized the treatment of hypercholesterolemia. They are the most efficient agents for reducing plasma cholesterol, being also appreciated for their good tolerance. Angiographic studies have demonstrated that these compounds reduce the progression and may induce the regression of atherosclerosis. The beneficial effects of the HMG-COA reductase inhibitors are usually attributed to their capacity to reduce the endogenous cholesterol synthesis, by competingly inhibiting the principal enzyme involved. Since mevalonate, the product of HMG CoA reductase reaction is the precursor not only for cholesterol, but also for many other non steroidal isoprenoidic compounds, inhibition of this key enzyme may result in pleiotropic effects.
Our experiment was to investigate the effect of atorvastatin as hypocholesterolmic agent. This experiment was conducted Thirty six (36) one day old Cobb chicks ,where divided into three groups after 2 weeks, where a group was kept as negative control, non treated (GP.1), and another two groups treated orally with 0.02 and 0.05 % atorvastatin (GP.2) and (GP.3).
Our results showed that experimental treatment of atorvastatin had no significant change in erythrogram and leukogram data for the chickens treated with 0.02% and 0.05% atorvastatin from the control along the whole experiment.
Biochemical changes included increase in AST enzyme which rapidly disappeared after 4weeks post treatment.