الفهرس 
Pediiattriic Bronchiiall AstthmaOnly 14 pages are availabe for public view
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Abstract
Asthma is the most common chronic illness of childhood. It is a major global public health problem, Asthma affects an estimated 300 million individuals worldwide. Evidence shows that the prevalence of asthma is increasing, especially in children.
Assessment the degree of asthma inflammation is a challenge for all researches especially via non- invasive maneuver. Exhaled IL4 can be considered as a biological marker of airway inflammation in bronchial asthma. The current study measured the level of EBC-IL4 as a new inflammatory marker in different grades and control of asthma aiming at assessing its diagnostic value in grading of childhood asthma according to (GINA classification, exhaled condensate and spirometric pulmonary function test).
This work was conducted on 40 asthmatic patients from those regularly attending the Pediatric Chest Clinic all patients treated with ICS, The age of the children included in the study ranged between 6-16 years with mean age 9.6 ±3.1 years males with female to male ratio 1: 1.9. Forty (40) age and sex matched- clinically healthy children were included as a control group.
The asthmatic patients were further subdivided into:
- According to asthma severity into, moderate persistant (n=20) and severe persistant ((n=20).
- According to asthma control during the past three months into controlled (n=10), partially-controlled (n=20) and uncontrolled (n=10).
All studied patients were subjected to the following:
Full medical history, thorough clinical examination and Spirometric pulmonary function testing .Measurement of serum IgE for atopic status was done. Exhaled breath condensate was collected using a condenser (EcoScreen) it was a noninvasive method which has the potential to be useful for monitoring airway inflammation in patients with respiratory diseases, including children. Analysis of samples was done using ELISA technique.
Collected data were reviewed, coded, and entered PC where statistical analysis was done using SPSS (statistical package for social science) version XI which revealed that:
There was a higher level of EBC-IL4 detected in cases (62.02 ±22.63 pg/dl) when compared to healthy control group (15.95±3.36 pg/dl) with cut-off value 62.5 pg/ml with sensitivity 80% and specificity 15%. It was higher in severe asthmatics (76.75±17.75) than in moderate asthmatics (47.3±16.73) and it was higher among uncontrolled patients (90±15.13) followed by partially controlled patients (62.85±6.59) then controlled patients (32.4±7.35).
Also there was a highly significant negative correlation between EBC-IL4 level & FEV1% in asthmatic patients.
There was a significant positive correlations Between EBC-IL4 level and Eosinophilic count.
In conclusion, EBC–IL4 level can be considered as a new non invasive marker for assessment different grades of asthma severity and control. It may be a target of future therapeutic interventions.