الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Objective— This study was carried out to evaluate mild cognitive impairment (MCI) clinically and radiologically, furthermore we followed those patients althrough the period of 2 years (from March, 2009 to Februrary,2012 ) to evaluate whether or not these patients will convert to dementia.
Methods—The participants were 50 patients with MCI in addition to 20 normal control subjects .We performed a group of neuropsychological test battery including measures of global cognitive abilities, memory, orientation, attention, executive functions, language, and visuospatialabilities. The Functional Activities Questionnaire (FAQ) was used for instrumental activities of daily living (IADLs). Radiological evaluation included DWI for the temporal , parietal ,occipital ,frontal regions of interest as well as the hippocampus and corpus callosum. Volume measurements of the hippocampus and amygdala were performed. 1MR spectroscopy voxels were placed over the hippocampus , temporal and parietal areas.
Results— There were no statistically significant differences between MCI patients as a whole and control as well as between convertor and stable MCI patients as regards age, sex, education, vascular risk factors ”Diabetes, Hypertension , Heart disease , Dyslipidaemia” and neuropsychiatric symptoms” depression , anxiety” (P>0.05).There were statistically significant differences between MCI patients as a whole and control as regard all the neuropsychological tests (p<0.05) except intelligent quotient(IQ).Regarding convertor and stable MCI, there were statistically significant differences between convertor and stable MCI patients as regard all the neuropsychological tests exceptminimental state examination (MMSE),working memory and associate learning (p<0.05).The top ranked predictor of conversion from MCI to AD was Mi/Cr ratio of the hippocampus (sensitivity=90% and specificity=95%) .The ADC of the parietal region ranked second (sensitivity=66% and specificity=85%) and the volumetry of the hippocampus ranked third (sensitivity=40% and specificity=95%) in terms of discriminability. Other radiological measures emerged lower in the list.
Conclusions— Neuropsychology and neuroradiology has contributed importantly to the characterization of MCI patients and its differentiation from cognitive changes associated with normal aging.