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Abstract Immunologic factors, notably immunity to sperm, must be considered part of any comprehensive appraisal of human infertility .(Jones, 1988). Antisperm antibodies, although not an absolute cause of infertility, reduce the likelihood of pregnancy, and the concentration of such antibodies in reproductive tract secretions appears to infeluence the degree of fertility impairment. Although antisperm antibodies (ASA) should be suspected in couples with repeated abnormal postcoital tests, sperm agglutination, or reduced sperm motility, immunological factors also play a significant role in the pathogenesis of approximately ten to twenty percent ot cases of unexplained infertility, that is couples with normal semen analysis and no abnormalities on the routine investigation of both partners. Detection of antisperm antibodies is therefore, an important step in the workup of an infertile couple. (Mcclure, et aL, 1989). |