الفهرس 
Aim of the thesisOnly 14 pages are availabe for public view
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Abstract
The thesis contains three parts, all of which concerned with the new transition metal complexes of piperidine-2-carboxylic acid (DL-H2pa) and 5-chloro-2,3-dihydroxypyridine (H2chp).
Part I: Introduction
This part is dealing with cancer, carcinogenesis, causes of cancer and cancer treatment. The anticancer activity of some transition metal complexes against different types of cancers have been also reported with their limitations due to their side effects.
A brief knowledge about carboxylato and cyclic amino acids, hydroxypyridines derivatives and their complexes were reported. Moreover, the corrosion inhibition efficiency of N,O donors were reported.
Part II: Experimental
This chapter is concerned with synthesis of piperidine-2-carboxylic acid (DL-H2pa) and 5-chloro-2,3-dihydroxypyridine (H2chp) transition metal complexes, trans- [Zn2(µ-Ca)2(Hpa)2Cl6].1/3H2O, [Zn(H2pa)Cl4], [Pd(Hpa)(bpy)]Cl, [Pd(PPh3)2(pa)], [Pt(Hpa)(bpy)]Cl, [Pt(pa)(PPh3)2].CH2Cl2, [Zn(Hpa)(AcO)(H2O)2], [Zn(Hchp AcO)], cis-[MoO2(Hchp)2], [Ag(Hchp)(PPh3)2], [M(chp)(PPh3)2] (M(II) = Pd, Pt). Elemental analysis, molar conductivity and physical and chemical measurements are reported. The methods and measurements of the anticancer activity against the serous ovarian cancer ascites (OV90) cell lines are also reported. In addition, the electrochemical cell used for corrosion inhibition measurements (potentiodynamic polarization and impedence spectroscopy) and the theoretical calculations are included.
Part III: Results and Discussion
This part is concerned with the characterization of the isolated complexes by a variety of physical and chemical techniques including X-ray crystal structure, Raman, IR, electronic, 1H NMR, mass spectra, conductometric and thermal measurements.
Applications
-Anticancer activity of DL-H2pa, H2chp and their complexes against the serous ovarian cancer ascites (OV90) cell line.
The in vitro anticancer activity of free DL-H2pa and its complexes; trans-[Zn2(µ-Ca)2(Hpa)2Cl6], [Pd(bpy)(Hpa)]Cl and [M(pa)(PPh3)2] (M(II) = Pd, Pt) as well as free H2chp and its complexes, [Zn(Hchp)(AcO)], cis- [MoO2(Hchp)2], [Ag(Hchp)(PPh3)2] and [M(chp)(PPh3)2] (M(II) = Pd, Pt) were tested against serous ovarian cancer ascites OV 90 cell line in comparison to cis-platin as a reference. Among DL-H2pa complexes, the complex [Pt(PPh3)2(pa)] exhibits the highest growth inhibitory activity with mean IC50 value of 43.13 μM. In case of H2chp complexes, both [Ag(Hchp)(PPh3)2] and [Pt(chp)(PPh3)2] exhibit the highest growth inhibitor activity with mean IC50 values of 7.20 and 5.71 μM, respectively; the IC50 value of cis-platin being 31.06 μM.
- Effect of DL-H2pa, H2chp and H2sap as corrosion inhibitors for Cu10Ni alloy in 0.5M HCl using potentiodynamic polartization and impedance spectroscopy
The corrosion inhibitors were selected on the bases of ring saturation as well as the number of active sites. DL-H2pa is a saturated heterocyclic (one N) compound, H2chp is an unsaturated heterocyclic (one N) ring compound and 4-hydroxysalicylidene-2-amino pyrimidine Schiff base (H2sap) is containing pyrimidine heterocyclic (two N and NH2), azomethine and 2,4-dihydroxy aromatic ring.