الفهرس 
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Abstract
Background Psoriasis is a chronic, inflammatory skin disease
with approximate 2-3% prevalence in the general population. The
etiology of psoriasis is not fully understood, but it appears to be multifactorial,
involving both genetic and environmental influences. Although
the precise mechanism by which polymorphisms in IL23R influence the
disease process still requires further clarification, the associations and
functional evidence suggest that the IL23 pathway has a key role in the
pathogenesis of psoriasis. Objective is to study the role of IL23R
Arg381Gln SNP rs11209026 and other SNPs (rs2201841) of the IL23R
gene in psoriasis in the Egyptian patients. Methods This study included
30 psoriatic patients and 30 normal individuals. Real time PCR was
carried out for the analysis of rs11209026 SNP while PCR – RFLP was
performed for the analysis of IL23R gene SNPs (rs2201841). Results
Our results revealed that the (G) allele of rs11209026 (IL23R
Arg381Gln) is risky while the (A) allele is protective OR 6.510 (95% CI
1. 376 - 30.792).On the other hand, genotyping of rs2201841 showed no
significant difference in the 2 studied groups.
Conclusion Association of IL23R Arg381Gln with psoriasis indicates
that genes participating in IL23 signaling play a significant role in
psoriasis pathogenesis.
Key words: IL23Rgene, SNPs, Psoriasis, PCR-RFLP, Real time PCR