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Abstract Acute renal failure (ARF) has traditionally been defined as the abrupt loss of kidney function that results in the retention of urea and other nitrogenous waste products and in the dysregulation of extracellular volume and electrolytes. The loss of kidney function is most easily detected by measurement of the serum creatinine which is used to estimate the glomerular filtration rate (GFR). Increasing numbers of patients with acute renal failure are managed in the setting of an intensive care unit. Many such patients have multiorgan failure.Sepsis or both, with associated cardiovascular instability |