الفهرس 
PathogenesisOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus, especially type 2 diabetes, is a public health problem which has reached epidemic proportions due to the rapidly increasing rates of this disease worldwide. Target organ complications, secondary to diabetes, will be one of the most important medical concerns of the coming decades. A clear example is diabetic nephropathy (DN), which has become the single most frequent cause of end-stage renal disease, in other words: ’a medical catastrophe of worldwide dimensions’. Endoglin is expressed at low levels in resting endothelial cells (ECs) but it is highly expressed in vascular ECs at sites of active angiogenesis during embryogenesis and in inflamed tissues and healing wounds psoriatic skin inflamed synovial arthritis, upon vascular injury and in tumor vessels. Endoglin is also expressed in other tissues undergoing fibrosis such as the kidney and liver.