الفهرس 
Mechanism of Insulin ActionOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia, dyslipidemia, and altered protein metabolism with an increased risk of the development and progression of micro- and macrovascular complications. It results from defects in insulin production, insulin action, or both.Insulin which signifies the fed-state activates glycogen synthesis and suppresses gluconeogenesis and glycogenolysis by affecting posttranslational modification of the key enzymes and their gene expression.A key step in gluconeogenesis is the formation of phosphoenolpyruvate from oxaloacetate, which is catalyzed by phosphoenolpyruvate carboxykinase (PEPCK) enzyme.Augmented activity of PEPCK enzyme contributes to the maintenance of elevated plasma glucose in chemically induced diabetes and to normal plasma glucose in the fasting state.