الفهرس 
Recurrent MiscarriageOnly 14 pages are availabe for public view
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Abstract
Antiphospholipid syndrome represents about 15% of the causes of recurrent miscarriage, thus it
is the most important treatable cause.
Aim of the study: To evaluate whether anti annexin V and anti β2-glycoprotein I antibodies can
be used as independent risk factors for recurrent spontaneous miscarriage and to investigate
whether the determination of anti annexin V and anti β2GPI antibodies combined with that of
anticardiloipin antibodies would help to increase the diagnostic sensitivity of antiphospholipid
tests.
Material and method: 40 patients with history of recurrent miscarriage and 20 healthy fertile
females of matching age served as a control group. Anticardiolipin antibodies, anti-annexin V
antibodies and anti- β2-glycoprotein I antibodies were measured in both cases and controls by
ELISA.
Results: Samples positive for aCL IgG and IgM, anti-Anx V IgM and anti-β2GPI IgM antibodies
were significantly higher in cases with recurrent miscarriage than in control group: 20/40(50%),
18/40(45%), 17/40(42.5%) and 11/40(30%) respectively with P= 0.000, P=0.001, P=0.005 And
P=0.001 respectively.
Conclusion: The combined assay off anti-cardiolipin antibodies, anti-annexin V antibodies and
anti-beta 2 glycoprotein I antibodies increase the percentage of diagnosed cases of recurrent
miscarriage with antiphospholipid syndrome and thus prevent the use of unnecessary
anticoagulant therapy. Anti-annexin V antibodies and anti-β2 glycoprotein I antibodies
(especially of IgM isotype) can be used as independent risk factors in cases of recurrent
miscarriage.