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Abstract Three simple, sensitive and reproducible spectrophotometric techniques were used for determination of different pharmaceutical compounds such as serotonin 5-HT1D receptor agonists (zolmitriptan (ZMT), sumatriptan succinate (SMT) and eletriptan HBr (ELT)) and pipazethate hydrochloride (PZT) as anti-tissuve drug in pure forms and pharmaceutical preparations. The first spectrophotometric technique is charge transfer complex of ZMT and SMT with π-acceptors (TCNQ); 2,3-dichloro-5,6 dicyano-p-benzoquinone (DDQ) or p-chloranilic acid (p-CLA) in acetonitrile and charge transfer complex of ZMT, SMT and ELT with quinalizarine (Quiz) and alizarine red S (ARS). The second spectrophotometric technique is ion-pair complex formation of ZMT, SMT and ELT using Mo(V)-thiocyanate and SMT and ZMT using acid dyes (BCG, BCP, BPB and MO). The third technique is indirect redox spectrophotometric reaction for determination PZT with bromate–bromide mixture in acid medium and determination of unreacted bromine by reacting it with a fixed amount of methyl orange, indigocarmine. thymol blue, iron (II) with 1,10-phenanthroline or iron(II) with thiocyanate. The results of the analysis were validated statistically. The results were in good agreement and compared with those obtained with reported methods. |