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العنوان
Reactions with Heterocyclic Compounds Under Microwave Irradiation /
المؤلف
Elnahas, Fatma Alzahraa Mostafa.
هيئة الاعداد
باحث / Fatma Alzahraa Mostafa Elnahas
مشرف / Kamal Yusuf Sadiq
مشرف / Afaf Mohamed Abdel Hamid
الموضوع
Heterocyclic compounds - Synthesis. Microwave heating. Heterocyclic chemistry.
تاريخ النشر
2012.
عدد الصفحات
82 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
كيمياء المواد
تاريخ الإجازة
1/1/2012
مكان الإجازة
جامعة المنيا - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

I have reported a green, highly efficient synthesis of 2-arylbenzothiazoles using glycerol without catalyst at ambient temperature, thus, with the initial aim of optimising the experimental conditions, I explored the reaction of 2-amino thiophenol I and benzaldehyde IIa using glycerol as a solvent at ambient temperature which affords the desired 2-phenyl-1,3-benzothiazole IIIa in excellent yield. I explored the reaction with different aromatic and hetero aromatic aldehydes IIb-k, also with substituted 2-amino-thiophenol, and 2-aryl-1,3-benzothiazoles III b-k were obtained in excellent yields.
In order to study the effect of solvent on the reaction rate I carried out the same reaction in different solvents, such as H2O, acetone and CHCl3, under the same reaction conditions and the reactants were recovered almost unchanged. I am also studied the effect of the aromatic aldehyde substituents on the reaction rate and the overall yield.
A proposed mechanism to account for the formation of the reaction product was postulated.