الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 76 |  |  |
| | | from | 76 | | |
Abstract
SUMMARY And CONCLUSION
The luteal phase defect was defined by Jone, (1976) as a defect of corpus luteum progesterone output either in amount or duration which results in inadequate stimulation of the endometrium for the implantation of the blastocyst. To be of clinical significance, luteal phase defect must be present in repeated cycles.
Luteal support by natural progesterone either vaginal or systemic route is commonly used in infertility practice, Macklon and Fauser, (2000) reported luteal phase deficiency in cycles stimulated with Human menopausal gondotropins /Follicular stimulating hormone alone.
This study is a prospective controlled clinical trial that evaluates the significance of progesterone luteal supplementation after ovarian stimulation cycles with gonadotropin and intra uterine insemination among women with unexplained infertility.
This study included 30 couples with unexplained primary infertility attenting infertility center of Banda university hospital during period from June 2009 till February 2013.
Selection of couples with unexplained infertility was based on the following criteria:
• The duration of infertility is at least 1 year.
• Regular menstrual cycles with mid luteal progesterone level > 10ng/ml.
• Bilateral tubal patency confirmed with hysterosalpingography and/or laparoscopy.
• Normal semen analysis based on World Health Organization criteria (WHO) 1993.
• No endocrinal abnormalities affecting fertility status (thyroid disorders, hyperprolactinemia, hypogonadotrophic hypogonadisme, polycystic ovarian syndrome).
• Normal ovarian reserve (follicular stimulating hormone day3 level <15 IU/ml).
• Patient age < 40 years.
Patients in this study with primary unexplained infertility were treated by controlled ovarian stimulation with pure gonadotropin and intra uterine insemination for 3 cycles. Luteal phase support by vaginal progesterone was performed for 15 patients (study group) while the other 15 patients no luteal support was used (control group).
There was insignificant difference between study and control groups regarding duration of infertility, BMI, day3 folicular stimulating hormone, the amount and duration of gonadotropins intake, number of follicles and endometrial thickness.
The presented study clarified that, pregnancy rate / insemination cycle and pregnancy rate /couples were higher among couple whom subjected to luteal phase support with vaginal progesterone compared to patients without luteal phase support although the difference was insignificance.
CONCLUSION:
Luteal support with vaginal Progesterone is beneficial regarding pregnancy rate in patients with unexplained infertility having ovarian stimulation and intrauterine insemination cycles with pure gonadtropins.