الفهرس 
ANATOMYOnly 14 pages are availabe for public view
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Abstract
With the growing demand from patients for less invasive procedures, the shift from surgical extirpation to ablative local control of breast tumors is an emerging focus in breast cancer care. Following this continuum, investigators are studying percutaneous minimally invasive techniques to locally eradicate breast tumors. Cryoablation, laser ablation, and high-intensity focused ultrasound have been reported for ablation of benign and malignant breast lesions. Radiofrequency energy heats tissue, causing thermal destruction and cell death by coagulation necrosis. This technique has been used for ablation of liver, prostate, bone, and renal tumors; pharyngeal soft tissue; neural tissue, and brain lesions. This study was performed to determine the feasibility and safety of treating breast cancer with RFA.
Patients with biopsy proving stage I or stage II invasive breast cancer underwent RFA under general anesthesia followed by immediate MRM. Before RFA, all patients were confirmed to have a localized lesion measuring < 5 cm in greatest dimension using imaging modalities. The resected tumor mass examined histologically with H & E staining.
30 patients completed the treatment without RFA-related complications.
Histological evaluation of the ablated tissue using H & E staining revealed that complete coagulative necrosis did not occur in any patient; however, incomplete coagulative necrosis of malignant cells characterized by cytoplasmic eosinophilia and dark pyknotic nuclear chromatin was recorded in all patients.
This may be due to either the type of staining used or the timing between RFA and mastectomy or both.