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Abstract The use of in situ methods for the diagnosis of Arterial-CRBSI are demonstrated in this study as promising techniques that need further validation in a larger scale study. However, because of the low incidence of peripheral Arterial-CRBSI it will be difficult to show an impact of any new strategy unless very large numbers of patients are studied. Any new preventive strategy must be shown to be cost-effective. We recommend a realistic approach for routine diagnosis of CRBSI for both CVC and AC in clinical microbiology laboratories by means of the combination of semiquantitative superficial cultures and conventional peripheral blood cultures. These methods are easy to perform and low in cost. Negative results of both superficial culture swabs could practically rule out the catheter as the source of infection, thereby avoiding many unnecessary catheter removals. Further studies of this method for the diagnosis of CRBSI, is needed. Nevertheless, in cases in which CRBSI is suspected, a prudent attitude must be taken, because a small percentage of CRBSIs due to hematogenous seeding yield superficial cultures with negative results. |