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Abstract spectrophotometric determination of miconazole (MCNZ), tioconazole (TCNZ) and clotrimazole (CLMZ) drugs in pure and pharmaceutical preparations through the ion-pair formation reaction with bromocresol purple (BCP), bromocresol green (BCG) and Eriochrome cyanine R (ECR) reagent is described. Also Solid state investigation of the metal complexes of MCNZ, TCNZ and CLMZ drugs has been carried out to investigate the coordination behavior of the drugs with different coordination sites, toward some bi and trivalent metal ions like Mn(II), Fe(III), Ni(II), Co(II), Cu(II), Cr (III) and Zn(II). Key Words: Pharmaceutical preparation; spectrophotometry; miconazole, tioconazole and clotrimazole determination; bromocresol purple, bromocresol green, eriochrome cyanine R, metal complexes, elemental analyses, IR, Thermal analyses, biological activity. |