الفهرس 
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Abstract
Although the incidence of gastric cancer has recently declined,
gastric cancer remains one of the common malignancies worldwide and is
the second most common cause of cancer related death.
Gastric carcinomas exhibit various pathological features and show
great differences with regard to their histogenetic origin. Many different
systems have been proposed for the histological classification of gastric
carcinoma, but the most commonly used are those of WHO and Lauren.
According to WHO classification, gastric carcinoma was classified into
papillary adenocarcinoma, tubular adenocarcinoma, mucinous
adenocarcinoma, signet ring cell carcinoma and other variants. Laurefi
divided gastric carcinoma into two major types, intestinal type- and diffuse
type- carcinomas.
Several clinicopathologic features have been found to influence
survival of patients with gastric cancer. Of these, extent of the primary
tumor ~T) and nodal status (N), have been recognized as standard
prognostic factors in potentially curable gastric cancer. Research efforts are
underway to .identify either additional traditional risk factors or new
prognostic and predictive biomarkers based on cancer genetics, genomics,
and epigenetics. Recently, alterations in the composition of mucin-type
glycoproteins were reported in inflammatory, metaplastic, and malignant
diseases of the stomach.