الفهرس 
DIABETES MELLITUSOnly 14 pages are availabe for public view
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Abstract
T
he present study was designed to assess the disease progression of type-1 diabetes mellitus with adiponectin levels and to insulin dose and glycemic control at diagnosis. Thirty children and adolescents with newly diagnosed, type 1 diabetes between 2 and 17 years old were enrolled in the present study.
The results of the present study proved that:
1- As regard diabetes progression pattern, 3 cases (10.0%) were stable; 14 cases (46.7%) showed rapid progress; 10 cases (33.3%) showed slow progress and 3 cases (10.0%) showed remission.
2- Age ranged from 2 to 17 years with a mean of 9.56±2.86 and there was statistically significant variance between different patterns of diabetes progression as regard age (the oldest were slow progressors, then stable, remitters and the youngest were rapid progressors (12.10±0.85, 9.33±1.15, 8.66±1.15 and then 8.00±2.77 respectively).
3- BMI ranged from 13.90 to 23.50 with a mean of 18.26±2.63 and there was statistically insignificant variance between different patterns of diabetes as regard BMI.
4- There was statistically significant decrease of C peptide at 6 months in comparison to their values at diagnosis in rapid and slow progressors while there was increase of C peptide at 6 months in comparison to the values of C peptide at diagnosis in remitters.
5- There was statistically insignificant variance between studied groups as regard HbA1c at diagnosis, 3 or 6 months. On the other hand, there was statistically significant decrease in HbA1c in all patterns at 6 months in comparison to their values at diagnosis.
6- There was inverse (negative), moderate and statistically significant correlation between C peptide at 6 months and adiponectin level at diagnosis and at 3 and 6 months. In addition, there was proportional (positive), moderate and statistically significant correlation between adiponectin values at diagnosis, 3 and 6 months and insulin at 6 months.
7- Adiponectin level at diagnosis is a good predictor in remitters, but had less predictive power in rapid and slow progressors
In conclusion: the results of the present study support the importance of studying different patterns of progression of type-1 diabetes in detail after diagnosis, rather than simply determining clinical remission on the basis of insulin needs. It also, determines the usefulness of adiponectin in differentiating patterns and prediction of some patterns based on their values at diagnosis.